Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
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چکیده
منابع مشابه
Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria
One sentence summary: Engineered bacteria record an inflammatory response in an IBD mouse model and are genetically stable during long-term growth in the mouse gut. Abstract: Inflammation in the gut, caused by infection and autoimmunity, remains challenging to effectively detect, monitor, and treat. Here, we engineer a commensal mouse E. coli strain to record exposure to tetrathionate, a downst...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2017
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.3879